HORDB

ID: hor002371
Uniprot ID: Q8WMJ4
Protein name: Neurexophilin-3
Gene name: NXPH3
Organism: Macaca mulatta (Rhesus macaque)
Family: Neurexophilin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region

Sequence: NATGQGNISISLVPPSKAVEXHQXQQIFIEAKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYR
Length: 95(1-95)
Propeptide: NATGQGNISISLVPPSKAVEXHQXQQIFIEAKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYR
Signal peptide: NA
Modification: NA
Glycosylation: T1 N-linked (GlcNAc...) asparagine;T7 N-linked (GlcNAc...) asparagine
Mutagenesis: NA

Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q99P87-F1.pdb

hor002371_AF2.pdb

hor002371_ESM.pdb

Mass:	1240076	Formula:	C461H716N134O136S6
Absent amino acids:		Common amino acids:	S
pI:	8.76	Basic residues:	15
Polar residues:	30	Hydrophobic residues:	29
Hydrophobicity:	-42.95	Boman Index:	-18969
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.68
Instability Index:	4527.47	Extinction Coefficient cystines:	15720
Absorbance 280nm:	167.23